Wolves qualified for the Europa League last 16 despite Jonathan Calleri’s hat-trick condemning them to a narrow defeat at Espanyol.
The Premier League side travelled to Barcelona in full control of the tie after their emphatic 4-0 win at Molineux in the first leg, but it was the hosts who struck first through Calleri.
The Argentine forward tapped in his first European goal to give the hosts a glimmer of hope, before Barcelona-born Adama Traore’s away goal effectively killed the tie.
Espanyol began the second half requiring another five goals to advance but they continued to press and were rewarded when Calleri hit his second from the spot after Max Kilman was penalised for a high boot on David Lopez.
Wolves equalised for a second time when Matt Doherty side-footed Daniel Podence’s cross into an empty net, but the La Liga side had the final say on the night when Calleri rose well to head in his third in injury time.
The visitors could have taken the lead moments earlier but substitute Pedro Neto failed to hit an open goal after latching on to a misplaced backpass and rounding the goalkeeper.
The draw for the last 16 takes place on Friday at 12:00 GMT.